11 Best Peptide Serums for Face in 2025

Are you looking for a powerful skincare ingredient that can transform your complexion? Peptide serums are the secret weapon many skincare experts rely on for firm, plump, and youthful-looking skin.

But with so many options available, finding the right one can feel overwhelming.

This guide will walk you through the best peptide serums on the market, breaking down what they do and how they can benefit your skin.

Key Takeaways: Everything You Need to Know About Peptide Serums

Before we dive into the specific products, here are some essential facts about peptide serums that will help you make an informed decision:

• Peptides build proteins: Peptides are the building blocks of proteins like collagen and elastin, which are essential for firm, youthful skin.
• Different types serve different purposes: There are several types of peptides used in skincare, including signal peptides (boost collagen), carrier peptides (deliver trace elements), enzyme inhibitors (prevent collagen breakdown), and neurotransmitter inhibitors (relax facial muscles).
• Immediate and long-term benefits: Peptide serums provide immediate hydration while working to strengthen and restore your skin over time.
• Work well with other ingredients: Peptides play nicely with other skincare ingredients like hyaluronic acid, vitamin C, and retinol, enhancing their effects.
• Universal skin compatibility: Most peptide serums are gentle enough for all skin types, including sensitive skin.
• Best application time: For optimal results, apply peptide serums morning and night after cleansing and before moisturizing.
• Visible results timeline: While some hydration benefits appear immediately, most users see significant improvements in firmness and wrinkle reduction after 4-12 weeks of consistent use.
• Look for key peptides: Some of the most effective peptides include Matrixyl 3000, copper peptides, Argireline, and Leuphasyl.
• Concentration matters: Higher concentrations of peptides generally deliver better results, so look for products that list peptides near the top of the ingredient list.
• Storage tips: Keep your peptide serum in a cool, dark place to maintain its efficacy, as some peptides can break down when exposed to light and heat.

Now, let’s explore the 11 best peptide serums that can transform your skincare routine.

Good Molecules Super Peptide Serum – Best Budget-Friendly Option

Good Molecules Super Peptide Serum stands out as an affordable yet effective option for anyone wanting to dip their toes into peptide skincare. This water-based formula delivers powerful results without breaking the bank.

Features:

• Contains copper tripeptides to reinforce skin firmness
• Includes acetyl hexapeptide-8 and acetyl octapeptide-3 to reduce fine lines
• Lightweight, water-based formula
• Free from fragrance, gluten, and animal testing
• pH balanced at 6.09

Pros:

• Absorbs quickly without any sticky residue
• Gentle enough for sensitive skin
• Works well under moisturizer and makeup
• Budget-friendly price point at just $12
• High-quality ingredients typically found in more expensive products

Cons:

• May not be potent enough for very mature skin
• Some users report needing more hydration afterward
• Results may take longer to appear than with higher-end products

The Good Molecules Super Peptide Serum is perfect for beginners or those on a budget. Users report noticeable improvements in skin texture and hydration within a few weeks. One customer even compared its results to Botox, showing significant reduction in the appearance of forehead lines after consistent use.

The Ordinary Multi-Peptide + Copper Peptides 1% – Best Science-Backed Formula

The Ordinary has gained a cult following for offering effective, no-frills skincare at affordable prices. Their Multi-Peptide + Copper Peptides 1% serum is a scientific approach to anti-aging.

Features:

• Contains 1% pure copper peptides
• Blue formula that absorbs without staining the skin
• Targets fine lines and improves skin elasticity
• Fragrance-free formula
• High concentration of active ingredients

Pros:

• Science-backed ingredients with proven results
• Visible improvements in skin texture and firmness
• Works quickly compared to many other peptide products
• Pairs well with other skincare products
• Reasonable price point at $32 for the quality of ingredients

Cons:

• Blue color may be off-putting to some users
• Slightly tacky feeling upon application
• Packaging can make it difficult to control dispensing

The Ordinary Multi-Peptide + Copper Peptides 1% has received glowing reviews from users of all ages. Many report significant improvements in skin firmness and reduced appearance of fine lines. The blue color comes from the copper peptides, which are known for their powerful skin-healing properties.

Collagen Peptide Serum by Eva Naturals – Best for Hydration and Repair

This collagen peptide serum by Eva Naturals offers a unique blend of peptides and botanical ingredients designed to hydrate and repair the skin.

Features:

• Contains a blend of peptides for collagen boosting
• Includes witch hazel and jojoba for soothing effects
• Aloe vera provides deep hydration
• Large 2 oz bottle offers great value
• Suitable for microneedling treatments

Pros:

• Lightweight texture that absorbs quickly
• Hydrates deeply without feeling greasy
• Soothes irritation with botanical ingredients
• Excellent value at $12.99 for 2 oz
• Works for all skin types, including sensitive skin

Cons:

• Contains some fragrance which may irritate very sensitive skin
• Pump dispenser occasionally gets clogged
• May not be potent enough for deep wrinkles

Eva Naturals Collagen Peptide Serum has garnered thousands of positive reviews, with users reporting softer, smoother skin with regular use. Many customers in their 60s and 70s note significant improvements in skin texture and brightness. The large bottle size makes this an economical choice for daily use.

Advanced Clinicals Multi Peptides Serum – Best for Targeting Multiple Signs of Aging

Advanced Clinicals Multi Peptides Serum is a comprehensive anti-aging formula designed to address multiple skin concerns simultaneously.

Features:

• Contains multiple peptides for collagen stimulation
• Includes quinoa and cica extract for soothing effects
• Vitamin E provides antioxidant protection
• Lightweight gel texture
• Generous 1.75 oz bottle

Pros:

• Targets multiple concerns including wrinkles, puffiness, and uneven tone
• Light gel formula feels refreshing on the skin
• Absorbs quickly without residue
• Affordable luxury at just $12.99
• Visible results with consistent use

Cons:

• Contains fragrance which some may find strong
• May not be hydrating enough for very dry skin
• Packaging is functional but not premium

Advanced Clinicals has created a multi-tasking serum that addresses various signs of aging simultaneously. Users report improvements in skin texture, reduced puffiness, and more even skin tone. The formula is particularly effective for firming sagging skin around the jawline and neck areas.

The Ordinary Multi-Peptide + Hyaluronic Acid – Best for Hydration and Firmness

Another stellar option from The Ordinary, this serum combines the power of multiple peptides with hyaluronic acid for a dual-action approach to skin aging.

Features:

• Multiple peptides target different aging concerns
• Hyaluronic acid provides deep hydration
• Specifically targets crow’s feet and loss of elasticity
• Lightweight, water-based formula
• Fragrance-free

Pros:

• Hydrates and firms simultaneously
• Absorbs quickly into the skin
• No irritation even around sensitive eye area
• Reasonable price at $19.90 for high-quality ingredients
• Excellent layering ability with other skincare products

Cons:

• Watery consistency may be difficult to apply
• Requires shaking before use as formula settles
• Glass dropper can be messy

This serum has earned impressive reviews, with many users calling it their “holy grail” product. The combination of peptides and hyaluronic acid creates both immediate and long-term benefits. Users report plumper, more hydrated skin with reduced appearance of crow’s feet and improved overall firmness.

Naturium Multi-Peptide Advanced Serum – Best Clean Formula

Naturium has quickly gained popularity for creating clean, effective skincare at accessible price points. Their Multi-Peptide Advanced Serum is no exception.

Features:

• Advanced multi-peptide blend for comprehensive aging concerns
• Clean, minimal formula without unnecessary additives
• Elegant, lightweight texture
• Free from parabens, sulfates, and phthalates
• 1 oz size in attractive packaging

Pros:

• Clean formula without controversial ingredients
• Elegant texture absorbs beautifully
• Visible firming effects on the skin
• Pairs well with other skincare
• Mid-range price of $24.99 offers good value

Cons:

• Smaller bottle size than some competitors
• May not be hydrating enough for very dry skin
• Some users report slight tingling upon application

Naturium’s Multi-Peptide Advanced Serum has quickly become a fan favorite for its clean formula and visible results. Users appreciate the elegant texture and the noticeable improvements in skin firmness and smoothness. The minimalist ingredient list makes this a great option for those with reactive skin.

Minimalist Multi Peptide Night Face Serum – Best for Overnight Repair

This overnight treatment from Minimalist works while you sleep to boost collagen and reduce wrinkles.

Features:

• Contains 7% Matrixyl 3000 for powerful anti-aging effects
• 3% Bio-Placenta adds additional rejuvenating benefits
• Specifically formulated for nighttime use
• Deeply hydrating formula
• Suitable for both women and men

Pros:

• High concentration of active ingredients
• Works overnight for continuous benefits
• Visible reduction in fine lines and wrinkles
• Affordable luxury at $12.99
• Simple, straightforward formula without fillers

Cons:

• May feel slightly sticky on the skin
• Not suitable for daytime use under makeup
• Some users find the scent slightly medicinal

Minimalist Multi Peptide Night Serum provides overnight repair with its high concentration of Matrixyl 3000, one of the most well-researched peptide complexes. Users report waking up to smoother, plumper skin with reduced fine lines. The overnight formula allows for deeper penetration and continuous benefits while you sleep.

Cetaphil Healthy Renew Anti Aging Face Serum – Best for Sensitive Skin

Cetaphil is known for gentle formulations that work well for sensitive skin, and their peptide serum continues this tradition.

Features:

• Peptides combined with niacinamide for multiple benefits
• Retinol alternative for those who can’t tolerate traditional retinol
• Vitamin B complex provides additional skin support
• Fragrance-free formula
• Dermatologist tested for sensitive skin

Pros:

• Extremely gentle on sensitive skin
• No irritation or redness
• Effective alternative to harsher anti-aging ingredients
• Reliable brand trusted by dermatologists
• Reasonable price at $18.83

Cons:

• May not be potent enough for deep wrinkles
• Simple packaging lacks luxury feel
• Results may take longer than with more concentrated formulas

Cetaphil’s Healthy Renew serum is perfect for those with sensitive skin who still want anti-aging benefits. The combination of peptides and niacinamide addresses multiple concerns like fine lines, uneven texture, and loss of firmness without causing irritation. Users with rosacea and eczema report being able to use this serum without any adverse reactions.

Medik8 Liquid Peptides – Best Professional-Grade Formula

Medik8 is a professional-grade skincare brand, and their Liquid Peptides serum represents their science-backed approach to skin aging.

Features:

• Regenerating multi-peptide complex
• Smooths wrinkles and fine lines
• Hydrating, brightening, and plumping benefits
• Elegant, lightweight formula
• 1.0 oz in professional packaging

Pros:

• Professional-grade formula used by estheticians
• Visible results in skin texture and firmness
• Multiple peptides for comprehensive benefits
• Elegant texture that sinks in immediately
• Plays well with other skincare products

Cons:

• Higher price point at $66
• May not be necessary for younger skin
• Simpler packaging than some luxury brands

Medik8’s Liquid Peptides serum is worth the splurge for those seeking professional-grade results. The multi-peptide complex delivers visible improvements in skin texture, firmness, and overall luminosity. Users report that a little goes a long way, making the higher price point more justifiable.

TruSkin Peptide Serum For Face – Best with Botanical Ingredients

TruSkin combines peptides with botanical ingredients for a holistic approach to skin aging.

Features:

• Peptides combined with amino acids
• Green tea, aloe, and vitamins B5 & E
• Supports skin barrier function
• Helps boost skin’s natural collagen
• Creates firmer-looking skin appearance

Pros:

• Botanical boost from green tea and aloe
• Supports skin barrier health
• Gentle yet effective formula
• Good value at $15.99
• Works for multiple skin types

Cons:

• Some users find the texture slightly tacky
• Results may take consistent use to become visible
• Pump sometimes dispenses too much product

TruSkin’s Peptide Serum stands out for its combination of peptides with skin-loving botanical ingredients. The addition of green tea provides antioxidant benefits, while aloe soothes and hydrates. This makes it a great option for those who prefer natural ingredients alongside active peptides. Users report improvements in skin texture and firmness with regular use.

AMPLE:N Peptide Shot Serum 2X – Best Korean Skincare Peptide Serum

Korean skincare is known for innovative formulations, and AMPLE:N’s Peptide Shot Serum brings this expertise to peptide technology.

Features:

• Intensive age-defying concentrate
• Formulated with peptide threads
• Targets wrinkles and improves firmness
• Lifts sagging skin
• Generous 3.38 fl.oz size

Pros:

• Larger size than most competitors
• Korean skincare technology for cutting-edge results
• Concentrated formula for visible firming
• Plumps and repairs aging skin
• Good value at $27.99 for the size

Cons:

• Less recognizable brand in Western markets
• Ingredient list may be difficult to understand
• Some users find the scent too strong

AMPLE:N Peptide Shot Serum harnesses Korean skincare innovation with its intensive peptide formula. The serum is particularly effective for lifting sagging skin and improving overall elasticity. The larger bottle size provides excellent value, and users report visible improvements in skin firmness and reduced appearance of wrinkles with consistent use.

When and How to Use Peptide Serums

For best results, apply your peptide serum twice daily, in the morning and evening. Here’s how to incorporate it into your routine:

1. Cleanse your face thoroughly.
2. If you use a toner, apply it next.
3. Apply your peptide serum while your skin is still slightly damp.
4. Allow the serum to absorb for 30-60 seconds.
5. Follow with moisturizer and sunscreen (in the morning).

Peptide serums work well with most other skincare ingredients, but for maximum effectiveness, avoid using them at the same time as direct acids like AHAs or BHAs, which can alter the pH and reduce peptide efficacy.

FAQs About Peptide Serums

What are peptides in skincare?

Peptides are short chains of amino acids that act as building blocks for proteins like collagen and elastin in your skin. They signal your skin to produce more collagen, resulting in firmer, younger-looking skin.

How long does it take to see results from peptide serums?

Most people notice hydration benefits immediately, but significant improvements in wrinkles and firmness typically take 4-12 weeks of consistent use.

Can I use peptide serum with vitamin C?

Yes, but apply them at different times. Use vitamin C in the morning for antioxidant protection and peptides in the evening for repair.

Are peptide serums suitable for all skin types?

Most peptide serums are gentle enough for all skin types, including sensitive skin. However, always check the complete ingredient list for potential irritants.

Should I use peptide serum before or after moisturizer?

Apply peptide serum before moisturizer. Serums have smaller molecular structures that need to penetrate the skin, while moisturizers create a protective barrier.

How often should I use peptide serum?

For best results, use peptide serum twice daily, morning and night.

Can I use retinol with peptide serum?

Yes, but use them at different times. Retinol works best at night, while some peptide serums can be used morning and night.

Are expensive peptide serums better than affordable ones?

Not necessarily. The effectiveness depends on the specific peptides used, their concentration, and the overall formulation. Many affordable options provide excellent results.

Can peptide serums replace Botox?

While peptide serums can improve the appearance of fine lines and wrinkles over time, they work differently than Botox and typically provide more subtle results.

Do peptide serums expire?

Yes, most peptide serums have a shelf life of about 12 months after opening. Check the product packaging for specific information.

Last update on 2025-04-28 / Affiliate links / Images from Amazon Product Advertising API Some of the links on this website are affiliate links, which means that at no additional cost to you, I earn a commission if you click through and make a purchase. I only recommend products and services that I believe will add value to my readers. Thank you for your support!